When does Tri-Luma® 
Cream begin working?

Tri-Luma® Cream (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) is indicated for the short-term (up to 8 weeks) treatment of moderate-to-severe melasma of the face. It is not for long-term use (more than 8 weeks) or for the maintenance of melasma symptoms. 

In studies, patients experienced improvement of their melasma with the use of Tri-Luma® Cream as early as 4 weeks. After 8 weeks of treatment with Tri-Luma®Cream, most patients had at least some improvement. Some had their dark spots clear up completely (38% in one study and 13% in another), but most subjects had their melasma recur after treatment was discontinued.