Stopping treatment with 
Tri-Luma® Cream

Stop using Tri-Luma® Cream (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) and contact your doctor if you experience:

  • Severe or continued irritation, blistering, oozing, scaling, or crusting
  • Severe burning or swelling of your skin
  • Irritation of your eyes, nose, or mouth
  • Any type of breathing problem
  • Blue-black coloration on your skin where the cream was applied


If you become pregnant while taking Tri-Luma® Cream, tell your doctor right away.You should discuss the chances that your baby may be harmed. Using Tri-Luma®Cream early in pregnancy may be more likely to produce birth defects than using it later in pregnancy. 

Additionally, Tri-Luma® Cream is indicated for the short-term (up to 8 weeks) treatment of moderate-to-severe melasma of the face. It is not indicated for long-term use (more than 8 weeks) or for the maintenance of melasma symptoms.

Take the melasma check test